BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME

POSITION TITLE

Hospital Frédéric

Directeur de Recherche, INRA

eRA COMMONS USER NAME

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION

Institut National Agronomique Paris-Grignon University of Montpellier II University of Montpellier II University Paris-Sud Orsay

DEGREE (if applicable)

Engineer M.Sc. Ph.D. Habilitation.

YEAR(s)

1984-1987 1987 1992 2002

FIELD OF STUDY

Agriculture Ecology & Evolution Quantitative Genetics Plant Sciences

A. Positions and Honors. Positions and Employment 1989-1992 Attaché Scientifique Contractuel, INRA Animal Genetics, Toulouse. 1992-2003 Chargé de Recherche INRA Plant Genetics and Breeding, Gif sur Yvette 2003 Directeur de Recherche INRA Plant Genetics and Breeding, Gif sur Yvette 2005-2007 Visiting scientist (detached), Lab. Theoretical Physics (LPTMS) Université Paris Sud Orsay. Other Experience and Professional Memberships 1992 Organizer of symposium « Réunion annuelle du groupe de Biologie et Génétique des Populations », Toulouse. 1999 Organizer of symposium « QTL-MAS Meeting », Paris 1999 Organizer of symposium “Rencontres INRA de Méribel”. 2000 Organizer of symposium Eucarpia Section ‘Biometrics in Plant Breeding’, Paris 1999-2004 Group leader « Génétique Quantitative Fondamentale » INRA, Gif sur Yvette 2002Associate Editor, Genetica B. Selected peer-reviewed publications (in chronological order). Lanneluc, I., Hospital, F., Chevalet, C., Elsen, J.-M., Gellin, J. (1992). Genetic analysis of fingerprints in mérinos d'arles x booroola merino crossbred sheep, Animal Genetics, 23: 339-346. Hospital, F., Chevalet, C., Mulsant, P. (1992) Using markers in gene introgression breeding programs, Genetics, 132: 1199-1210. Hospital, F., Chevalet, C. (1993) Effect of population size and linkage on optimal selection intensity., Theor. Appl. Genet., 86: 775-780. Fournet, F., Hospital, F., Elsen, J.-M. (1995) A FORTRAN program to simulate the evolution of genetic variability in a small population. Comput. Appl. Biosci., 11: 469-475. Hospital, F., Chevalet, C. (1996) Interactions of selection, linkage and drift in the dynamics of polygenic characters. Genetical Research, 67: 77-87. Hospital, F., Dillmann, C., Melchinger, A. E. (1996) A general algorithm to compute multilocus genotype frequencies under various mating systems. Comput. Appl. Biosci., 12: 455-462. Hospital, F., Charcosset, A. (1997) Marker-assisted introgression of quantitative trait loci. Genetics, 147: 14691485. Hospital, F., Moreau, L., Lacoudre, F., Charcosset, A., Gallais, A. (1997) More on the efficiency of marker assisted selection. Theor. Appl. Genet., 95: 1181-1189. Moreau, L., Charcosset, A., Hospital, F., Gallais, A. (1998) Efficiency of marker assisted selection in populations of finite size. Genetics, 148: 1353-1365. Biographical Sketch Format Page

Hospital, F., Goldringer, I., Openshaw, S. (2000) Efficient marker-based recurrent selection for multiple quantitative trait loci. Genetical Research, 75: 357-368. Bost, B., De Vienne, D., Hospital, F., Moreau, L., Dillmann, C. (2001) Genetic and nongenetic bases for the Lshaped distribution of quantitative trait loci effects. Genetics, 157: 1773-1787. Hospital, F. (2001) Size of donor chromosome segments around introgressed loci and reduction of linkage drag in marker-assisted backcross programs Genetics, 158: 1363-1379. Servin, B., Hospital, F. (2002) Optimal positioning of markers to control genetic background in marker assisted backcrossing. J. Hered. 93: 214-217. Servin, B., Dillmann, C., Decoux, G., Hospital, F. (2002) MDM : a program to compute fully informative genotype frequencies in complex breeding schemes. J. Hered. 93: 227-228. Bouchez, A., Hospital, F., Causse, M., Gallais, A., Charcosset, A. (2002) Marker assisted introgression of favorable alleles at quantitative trait loci between maize elite lines. Genetics, 162: 1945-1959. Hospital, F., Decoux, G. (2002) Popmin: a program for the numerical optimization of population sizes in marker-assisted backcross programs. J. Hered., 93: 383-384. Dekkers, J., Hospital, F. (2002) The use of molecular genetics in the improvement of agricultural populations. Nature Reviews Genetics, 3: 22-32. Thabuis, A., Palloix, A., Servin, B., Daubèze, A.M., Signoret, P., Hospital, F., Lefebvre, V. (2004) Markerassisted introgression of 4 Phytophthora capsici resistance QTL alleles into a bell pepper line: validation of additive and epistatic effects. Molecular Breeding, 14: 9-20. Lecomte, L., Duffé, P., Buret, M., Servin, B., Hospital, F., Causse, M. (2004) Marker-assisted introgression of five QTLs controlling fruit quality traits into three tomato lines revealed interactions between QTLs and genetic backgrounds. Theor. Appl. Genet., 109: 658-668. Servin, B., Martin, O. C., Mezard, M., Hospital, F. (2004) Toward a theory of marker-assisted gene pyramiding. Genetics, 168: 513-523. Wall, E., Visscher, P. M., Hospital, F., Woolliams, J. A. (2005) Genomic contributions in livestock gene introgression programmes. Genet. Sel. Evol., 37: 291-313. Hospital, F. (2005) Selection in backcross programmes. Phil. Trans. R. Soc. B, 360: 1503-1512. Martin, O. C., Hospital, F. (2006) Two- and three-locus tests for linkage analysis using recombinant inbred lines. Genetics, 173: 451-459. Chevin, L. M., Hospital, F. (2006) The hitchhiking effect of an autosomal meiotic drive gene. Genetics, 173: 1829-1832. Computer Software Freely downloadable programs (http://moulon.inra.fr/~fred/programs/): FREQ (Mathematica notebooks) A general algorithm to compute multilocus genotype frequencies under various mating systems mdm (ANSI C, sources and executables) A program to compute fully informative genotype frequencies in complex breeding schemes popmin (ANSI C, sources and executables) A program for the numerical optimization of population sizes in marker-assisted backcross programs grafgen (ANSI C, sources and executables) A program to analyse the genomic composition of individuals in inbred pedigrees. grafgen also draws Precision Graphical Genotypes C. Research Support « Stratégies d'introgression de caractères polygéniques assistées par marqueurs: évaluation méthodologique et validations expérimentales » (mais, tomate et piment), programme prioritaire INRA « Génome et fonction » (1,7~MF demandés sur 3 ans, retenu) . Role : coordinator PI. Projet de création de l'IFR « La plante et son environnement » Biographical Sketch Format Page

«Mesures des paramètres génétiques sans contrôle du pedigree et de l’environnement». ATP CIRAD 2003 (Bouvet PI) Renouvellement du GDR CNRS 1928 « Génomique des populations » (M. Veuille PI), 2003-2006. « Génétique quantitative et analyse génomique de la variabilité épigénétique (EPIVAR) », Génoplante 2004, co-PI with V Colot. Poste de Professeur Invité Université Paris XI pour S. Gavrilets, 2004, PI. CDD INRA pour l’accueil en détachement de O. Martin (Pr. Univ. Paris XI, Dep. Physique). , 2004, PI. Demande de financement pour l’accueil d’un postdoctorant. MENRT 2004, PI. « Génétique Quantitative : théories et modélisations appliquées aux expériences », Demande de Plan PluriFormation (PPF), Univ. Paris-Sud, 2005. (Martin PI) « The effect of selection at multiple loci on molecular polymorphism within a chromosomal region (Selmultiloc) » ANR Programme Blanc 2006, Vekemans PI. Role: PI of project 3.

Biographical Sketch Format Page