Mikhaeel 40 43 79 74 NR (10cm, ESR > 50, ≥3 regions, Age > 50, LD histology
Israel H2 Trial for Advanced Hodgkin Lymphoma IPS 0-2
IPS 3-7
2 x ABVD
2 x BEACOPP esc.
PET
PET
Negative
Positive
Negative Positive
4 x ABVD 2 x BEACOPP esc. PET
2 x BEACOPP esc. Negative
2 x BEA esc. (+ RT)
PET Positive + progression
Positive + progression
Salvage
Negative
2 x BEA esc. (+ RT)
Salvage
Role of Interim PET in HL • Dann et al, abstract A4 – 275 patients (ongoing study)
• Conclusions • Minimal tx for early stage • Decrease tx for advanced
Role of Interim PET in HL • Miltényi et al, abstract A9 – n =108 – Treatment not specified – NPV - 93.8 – PPV - 59.2 – Added value of LDH, age, histology (cMC)
Role of Interim PET in HL • Angelopoulou, abstract A5 – Predicts outcome with ASCT – Some positive patients still benefit – Time points/interpretation not clear – Chemosensitivity important vs PET +/– Posttreatment PET a better predictor
Interim PET in MCL • Ribakovsky et al – abstract A16 – Predicts neither PFS nor OS – ASCT may have improved outcome
• Bourre et al – abstract A17 – 39 elderly patients – No intervention – Predicts outcome
Interim PET in NKT-cell NHL • Khong, et al – abstract A19 – 23 pts – Mid-tx PET only predictor of PFS, OS
Outcome of patients with T/NK lymphomas. PET-
ALK+ vs -
PET+
Interim PET ALK-s
PET-
PET- Post Tx
PET+
Cahu et al, Ann Oncol, 22:705, 2011
PostTx PET ALK-s
Problems in Interpreting Data • Small numbers of heterogeneous pts • Was there standardization/adjudication of interpretation? • Treatment not-specified/not standard • What do we do with the information? • How does it compare with post-tx PET? • Not clear that changing therapy makes a difference?
â¢82 newly-diagnosed HL patients stage (IIB-IVB); median FU 2 years. â¢6 ABVD/EBVD and radiotherapy. â¢The result of interim PET/CT did not affect treatment.
whole pedal stroke. The average cadence recorded for the SRM during this trial was 94. 13 rpm compared with. 54. 30 rpm for the PT hub. Figure 6a shows a ...
3rd International Workshop on Interim PET in Lymphoma. Menton, September 27, 2011. Poster Discussion. Poster discussion. NHL. Ulrich Dührsen. Department ...
Shallow water Pekeris waveguide. Sourc tinc Series. 2000L. Long range propagation. For both shallow aid deep watcr thc NPE is propagating the field the first ...
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