10:45-12:30
Session 2 : MRI; iron oxide particles Moderators: A. Leroy-Willig, R.N. Muller
T. Allkemper High-field MRA with iron oxide blood-pool contrast agents: field strength effects on vascular contrast enhancement in rabbits at 1.5 and 3.0 T F.K. Wacker, R Maes Interventional double contrast MR Angiography: intraarterial injections of SPIO particles SHU 555 C (Resovist®) in combination with true FISP imaging M. Taupitz VSOP-C184 as contrast Agent for MR imaging of atherosclerotic plaques: experimental results in rabbits M. Wiart MRI of cerebral ischemia with ultrasmall superparamagnetic particles of iron oxide in mice
PRELIMINARY PROGRAM
J.P. Fortin Use of magnetic nanoparticles as intracellular agents for hyperthermia
Tuesday, October 11
J.O. Barentsz Ferumoxtran-10 enhanced MR imaging in detection of metastases outside the normal surgical area in prostate cancer
17:00
Welcome desk at Hotel Ermitage
19:00
Welcome cocktail
12:30-13:30 Lunch
20:00
Dinner at Hotel Ermitage
13:30-15:30
Moderators: R. Brasch, T. Helbich
Wednesday, October 12 8:30-8:45 8:45-10:15
Session 3 : Targeting; tumor
R. Brasch MRI tumor characterization using Gd-GlyMe-DOTA-PerfluorooctylMannose-conjugate (gadofluorine M), a novel protein-avid contrast agent
Welcome address O. Clément, Convenor Session 1 : MRI; liver agents
Y. Ni The stromal mechanism: an inherent link between necrosis avid contrast agents (NACAs) and photodynamic therapy
Moderators: M. Taupitz, C.A. Cuénod V. Lorusso The hepatobiliary excretion of Gd-BOPTA does not interfere with the clearance of other drugs
B. Indrevoll New RGD peptide-based molecular imaging agents for detection of angiogenesis
S. Hirohashi Extraction rate of SPIO by the normal and gadolinium chloride treated liver
H. Kobayashi Sentinel node imaging of breast cancer in mice using a dual labeled nano-sized MRI/near infrared (NIR) optical hybrid contrast agent
E. Lee Analysis of hepatic uptake of anionic magnetic nanoparticles
G. Le Duc In vivo follow up of Gd-labeled liposomes concentrations in the rat bearing a glioma: a comparative study
J. Schnorr Comparison of VSOP-C184, gadopentetate dimeglumine, and ferucarbotran in T1-weighted dynamic and T2-weighted late MRI of focal liver lesions in rabbits
S. Lesieur PEG-ylated and fluorescent superparamagnetic liposomes provide a promising tool for combining in vivo imaging and therapy
C. Wirth Does dual contrast MRI of the liver improve the detection of focal liver lesions ? on-site results of a prospective multicenter study
F Estève High Z compounds for synchrotron stereotactic radiotherapy, developments and perspectives
R. Kuwatsuru Comparison of liver metastasis detectability from colorectal cancer between SPIO (superparamegnetic iron oxide particles)-MRI and diffusion weighted imaging
J.P. Weichert Preliminary imaging results with NM404 in lung cancer patients M. Tweedle Preclinical efficacy of 177Lu-AMBA, a radiotherapeutic targeting the GRP-receptor
10:15-10:45 Coffee break 1
15:30-16:00 Coffee break
H. Kobayashi Dendrimer-based nano-sized contrast agents for functional renal MRI: New insights into pathogenesis of acute renal diseases
16:00-16:30
Lecture : Imaging agents for PET; overview and prospective Daniel O. Slosman
16:30 -18:00
Session 4: Targeting; vascular - inflammation
U. Nyman The risk of contrast medium (CM) induced nephropathy (CIN) should be correlated to the ratio between dose in gram iodine and estimated glomerular filtration rate (eGFR)
Moderators: S Lesieur, J. Weichert
10:45-11:15 Coffee break
J. Meding The mechanism of gadofluorine accumulation in atherosclerotic lesions
11:15-12:30
Moderators: J. Barentsz, V. Runge
T. Cyrus Targeted MR nanoparticles for local anti-restenotic therapy following angioplasty
J.M. Esteban 1-molar Gadobutrol as a contrast agent for CT angiography of the aorta and pulmonary arteries: results with a 16-detector row scanner
D. Letourneur A new contrast agent for magnetic resonance imaging of the vascular walls
J.M. Esteban CT urography : Utility of 0.5 and 1 molar gadolinium chelates compared with an iodinated contrast medium
C. Corot Folate targeted high relaxivity Gadolinium chelate : in vitro binding affinity evaluation on purified folate binding protein and on KB tumor cells overexpressing folate receptors
V.M. Runge The efficacy of MultiHance at 1.5 and 3 Tesla in a rat brain glioma model
G. H. Simon Ultrasmall supraparamagnetic iron oxide-enhanced MR imaging of antigen-induced arthritis: a comparative study between SH U 555 C, ferumoxtran-10 and ferumoxytol
M. Saeed Blood pool contrast media (Vistarem) discriminates acutely infarcted from scarred myocardium on late enhancement B. Tombach Phase I clinical trial of Gadomer
H. E. Daldrup-Link Proof-of-concept of folate-receptor targeted MR Imaging of antigen induced arthritis
12:30-13:30 Lunch
Evening Dinner at Hotel Ermitage
Afternoon Optional guided tour to Fondation Gianadda at Martigny (Switzerland). Special exhibit “Masterpieces of French painting from the collection of the Pushkin State Art Museum of Moskow”
Thursday, October 13 8:30-9:15 9:30-10:45
Session 6 : MR agents; clinical applications
The Harry Fischer memorial lecture Michael F. Tweedle
Evening Dinner at Hotel Royal
Session 5 : Iodinated agents; tolerance
Friday, October 14
Moderators: H. Thomsen, R. Kuwatsuru R. M. Hammerstingl Diagnostic imaging with iobitridol: safety in a general population and tolerance in patients with rare risk factors. Results in 52.057 patients B. Elmståhl Nephrotoxicity of iodine contrast media (CM), iso-osmolar to plasma, in comparison with gadolinium CM after renal arteriography in an experimental porcine model
8:30-9:00
Lecture : Contrast agents for optical imaging W. Semmler
9:00-10:45
Session 7 : Molecular Imaging; optical – perfusion Moderators: A Klibanov, O. Clément
C. Bremer Planar and tomographic imaging of αvβ3 - expression in human tumor xenografts
K. Golman Effect of bicarbonate infusion on contrast-induced-nephropathy (CIN) 2
L. Fournier Exploring microvessels using intravital fluorescence microscopy: role of molecular weight of agents
F. Gazeau Detection of single cell by high field MRI D. L. Kraitchman Novel magnetic resonance contrast mechanism for combined tracking of the delivery of mesenchymal stem cells and interventional devices
H. E. Daldrup-Link Optical imaging of experimental arthritis with DiD labeled leukocytes before and after cortisone treatment
L. Darrasse In-vivo single-cell MRI of lymphocytes in tumors at 1.5 T using a superconducting surface coil
T.H. Helbich Hemoglobin, a physiological contrast media for optical molecular imaging of the female breast: computed-tomography-laser-mammography in the differentiation of benign and malignant breast lesions
K. Sieland Magnetic labeling and in vivo tracking of embryonic stem cells: efficacy, biological effects, high field detection limits and long term results
R. Pollard Contrast enhanced ultrasound and CT for quantifying response to anti-angiogenic therapy in a rat tumor model
C. Rivière Iron oxide nanoparticles as cell labeling contrast agent for noninvasive long term cell therapy monitoring by MRI: an abdominal aortic aneurysm model
D. V. Sahani Role of perfusion CT in monitoring anti-angiogenic response in patients with advanced hepatocellular carcinoma (HCC)
J. Barentsz In vivo MR tracking of magnetically labeled dendritic cells: First clinical experience
C.A. Cuenod Simultaneous placental perfusion and permeability assessment by dual echo contrast enhanced MRI in mice
15:30-16:00 Coffee break 10:45-11:15 Coffee break 16:00-17:00 11:15-12:30
Session 8 : US agents
Session 10: Round Table
Cellular imaging, the regulatory view point: diagnostics or therapeutics ?
Moderators: R. Mattrey, E. Wisner Evening Dinner at “Le Chalet du Golf”
R. Mattrey Dextran-coated PFOB emulsion: a potential targeted US contrast agent
Saturday, October 15
G. M. Lanza Fibrin-directed nanoparticle for combined imaging and local thrombolytic therapy
8:30-10:15
A.L. Klibanov Targeted ultrasound contrast agents for molecular imaging in high-shear flow
Session 11: Iodinated agents; tolerance - allergy Moderators: D Laroche, E Lasser
O. Lucidarme Shell-rupture detection for single ultrasound contrast microbubbles
A. Joubert Radiodiagnostic exams with iodinated contrast media may result in severe DNA damage resulting in cellular radiosensitization
M. Schneider Effects of high MI exposure during contrast echocardiography with SonoVue™ in the dog
T. Almén Vector-electrocardiographic (VECG) changes in pigs indicating risk of ventricular fibrillation (VF) after injections into the left coronary artery of mannitol or iodixanol solutions with or without electrolytes
E. Wisner Contrast-assisted ultrasound for sentinel lymph node detection; the effect of particle characteristics and node status on imaging efficacy
P. Dewachter Current concepts in the evaluation of immediate allergic reactions to contrast agents
T. Hölscher Real-time assessment and off-line quantification of flow dynamics in intracranial aneurysms using intra-operative contrast-specific ultrasound
D. Laroche Immediate reactions following ICM injection: Results of a 3-year prospective multicenter survey
12:30-13:30 Lunch 13:30-15:30
W. Pichler Immunological mechanisms of delayed-type hypersensitivity reactions to iodinated contrast media
Session 9 : MRI; cellular imaging
K. Brockow European multicenter study on contrast media hypersensitivity
Moderators: F Gazeau, J.Bulte 10:15-10:45 Coffee break
J. Bulte Instant magnetic labeling of stem cells using magnetoelectroporation 3
10:45-12:30 Session 12 : Molecular imaging; small animal - phage displaygene expression Moderators: C. Bremer, D. Letourneur
15:45-17:30
Session 14 : MRI; manganese - hyperpolarized gaz Moderators: H Daldrup, L Darrasse
M. Almajdub High- resolution X-ray microtomography of spleen in living mice
B. Stieltjes In vivo structural and functional imaging of the mouse spinal cord using manganese enhanced MRI
L. Hedlund Micro-CT and micro-DSA of small animal models of disease using iodinated conventional and blood pool contrast agents C. Burtea Phage display screening for peptides targeting the amyloid peptide Ab1-42 for molecular imaging of the senile plaques in Alzheimer disease
P. Leander Abdominal MRI made easy with orally administered manganese: A liver-specific contrast agent and a bowel marker
C. Laumonier Stealthy magnetophages, a new tool for Molecular Imaging
H.S. Thomsen Preliminary clinical experience with oral manganese (CMC-001) for liver imaging in daily routine
Q. Wang Use of in vivo imaging to follow siRNA-mediated reporter gene inhibition in a transgenic mouse skin model J. Räty Ultra-small iron oxide nanoparticle (USPIO)-labeled baculoviruses as novel MRI-agent for imaging viral vector biodistribution in vivo
H. Dekker Oral Manganese as contrast medium in detecting liver metastases with MR-imaging at 1.5 and 3T
A. Leroy-Willig In vivo Magnetic Resonance Imaging: use of extracellular contrast agent to quantify the efficiency and the toxicity of gene electrotransfer in rat muscle
R.M. Maes First use of intra-articular carbon dioxide (CO2) for MRarthrography; a feasibility study V. Stupar Non invasive hyperpolarized Helium3 imaging studies in rats under spontaneous breathing conditions using retrospective radial Cine imaging technique
12:30-13:30 Lunch 13:30-15:15
Session 13 : MRI; new agents-chemistry - relaxation
Y. Crémillieux Investigation of ozone exposure effects on rat pulmonary function using hyperpolarized Helium3
Moderators: S. Aime, T. Roberts D. Vera Mannosyl-Dextran: a potential multi-modality contrast agent targeting at mannose receptor J-L. Bridot Doubly luminescent gadolinium oxide nanoparticles as contrast agents for MRI
17:30-18:00
F. Schick Relaxivity of gadopentetate dimeglumine, gadobutrol and gadobenate dimeglumine in human blood plasma at 0.2 T, 1.5 T and 3 T
CMR Business meeting
Evening Closing reception at the CASINO
M. Port Design and pharmacomodulation of high relaxivity MR contrast agents T.P.L. Roberts A temperature-sensitive contrast mechanism for MRI: Curie temperature transition-based imaging
Sunday, October 16
M. Pagel Activatable MRI CEST Agents that detect enzyme activities
Morning Departure
S. Aime Novel Applications in the Field of MRI-CEST Agents 15:15-15:45 Coffee break
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