The history of intracavernous injections past present future

Why do you prefer ICI ? Sure/ No performance anxiety. Longer erections. Stay after ejaculation. Very few side effects ...
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Ronald Virag CETI ~Paris www.medisexe.com

It happened during a Michal 1 procedure Epigastric artery Papavérine

Clamp

2a

2b

2c The first intracavernous injection in february 1981

Early pionneers 1976-1980

In the meantime in Paris…

Group 1: « Non organic »  Group 2: « Arterial »  Group 3: « Venous and Mixed 

Giles S Brindley 1983/ Phenoxybenzamine

Adrian W Zorgniotti 1983/ Papaverine-Phentolamine

« CERITINE » Papaverine Alphablockers Dipyramidole Atropine PGE1 J. of Urology 1991

11

Self IC injections of etilefrine

Over 7000 patients on Intracavernous Injections 7000 6000 5000

4000 3000 2000 1000 0

Total ICI

Ronald Virag CETI-Paris H.Sussman, P.Bouilly, C.Daniel, K.Shoukry, F.Nollet, C.Richard, J.Floresco, H.Saltiel, D.Frydman, C.Lévy Et Catherine Arnion Académie de Chirurgie~Séance du 5 mai 2010

Why do you prefer ICI ? Sure/ No performance anxiety  Longer erections  Stay after ejaculation  Very few side effects 

Diagnosis Treatment

Research

The Present

Pivotal role of IC pharma test

Oral ICI Surgery

Treatment of a symptom

Cure or Prevent a disease

Compounds mixing NO donnors + Calcium blockers + K channel openers Improvement of IC Routes Guided molecules Micropumps

• • •



VEGF ENDOTHELIAL GENE THERAPY ADIPOSE TISSUE STEM CELL THERAPY ICI OF STEM CELLS FROM THE NEURAL CREST

AUTOLOGOUS CELLULAR THERAPY

A new promising treatment for ED and Lapeyronie’s disease AUTOLOGOUS CELLULAR THERAPY

CETI

Traitement de la Maladie de Lapeyronie par PRP + HLA-

Early Results in 19 patients 

Follow up  Mean follow up 11 months

 12 > 6 months



Complication  One hematoma



15/19 patients improved (74%)  8 excellent (patient quotation)  7 fair



Unchanged or Worsened 2